A.J. Baucum, Ph.D.Assistant Professor, Biology Department
Ph.D., Department of Pharmacology and Toxicology, GPA 3.895, University of Utah, Salt Lake City, UT.
B.S., Magna Cum Laude; Major: Biology, Minor: Spanish. Honors Program, GPA: 3.79. Loyola Marymount University, Los Angeles, CA
Courses Taught / Teaching
- K451 - Neuropharmacology
- Biol 56010 - Neurodegenerative Diseases (Formerly 697 Special Topics)
- Biol 60900 - Research Bootcamp (Formerly 59500 Special Topics)
Current research in the laboratory utilizes immunoprecipitation techniques, western blotting, imaging, and proteomics-based studies to characterize spinophilin protein complexes in health and disease.
Publications & Professional Activities
Tiffany A. Wills, Anthony J. Baucum II, Katherine M. Louderback, Yaoyi Chen, Johanna C. Gandy, Eric Delpire, David L. Tabb, Roger J. Colbran, Danny G. Winder. Chronic Intermittent Alcohol Disrupts the GluN2B-Associated Proteome and Specifically Regulates Group I mGlu Receptor Dependent Long-Term Depression. Addiction Biology. 2015 Nov 8. Epub ahead of print
Jonathon M. Wilson, Ann Marie Ogden, Sally Loomis, Gary Gilmour, Anthony J. Baucum, Belecky-Adams TL, Merchant KM. Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum. Neuropharmacology. 2015. August 7;99:379-386
Anthony J. Baucum II, Brian C. Shonesy, Kristie L. Rose, and Roger C. Colbran. Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain. ACS Chemical Neuroscience. 2015. Apr 15;6(4):615-31 (Co-corresponding author).
Shonesy BC, Wang X, Rose KL, Ramikie TS, Cavener VS, Rentz T, Baucum AJ 2nd, Jalan-Sakrikar N, Mackie K, Winder DG, Patel S, Colbran RJ. CaMKII regulates diacylglycerol lipase-a and striatal endocannabinoid signaling. Nat Neurosci 2013 Apr 16(4):456-63.
Anthony J. Baucum II, Abigail M. Brown, Roger J. Colbran. Differential association of postsynaptic signaling protein complexes in striatum and hippocampus. J. Neurochem 2013 Feb; 124(4):490-501
Anthony J. Baucum II, Stefan Strack, and Roger J. Colbran. Age-Dependent Targeting of Protein Phosphatase 1 to Ca2+/Calmodulin-Dependent Protein Kinase II by Spinophilin in Mouse Striatum. PLoS One. 2012;7(2):e31554
Anthony J. Baucum II, Nidhi Jalan-Sakrikar, Yuxia Jiao, Richard M. Gustin, Leigh C. Carmody, David L. Tabb, Amy-Joan L. Ham, Roger J. Colbran. Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach. Mol Cell Proteomics. 2010 Jun;9(6):1243-59.
Anthony J. Baucum II, Kristi S. Rau, Evan L. Riddle, Glen R. Hanson, Annette E. Fleckenstein. "Methamphetamine Increases Dopamine Transporter Complex Formation via a Dopamine- and Hyperthermia-Associated Mechanism" J Neurosci. 2004 Mar 31;24(13):3436-3443.
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Member, American Society for Mass Spectrometry 2011 - present
Member, American Society for Pharmacology and Experimental Therapeutics 2007 - present
Member, Society for Neuroscience 2004 - present
Honors, Awards and Grants
Mentoring Institute for Neuroscience Diversity Scholars (MINDS) Fellow 2016-2017
2nd place, Neuropharmacology Division of ASPET postdoctoral award competition, Experimental Biology Meeting 2009
Neuroscience Scholars Award, Society for Neuroscience 2007 - 2009
EMPOWER mentoring grant - Mentee 2013-2015
Best poster award Vanderbilt Kennedy Center Science Day, cellular and molecular neuroscience postdoc division. 2011
Vanderbilt University Medical Center Postdoc of the Year 2010
Best poster award Vanderbilt Postdoc Poster Symposium - Neuroscience division 2010
Best poster award Vanderbilt Brain Institute Neuroscience Retreat 2009
Best poster award Vanderbilt Kennedy Center Science Day, cellular and molecular neuroscience postdoc division. 2009
Best poster award Vanderbilt Postdoc Poster Symposium - Neuroscience division 2009
IDRC Pilot and Feasibility grant (2014-2015)
CTSI Core Pilot Grant (2014-2015)
NINDS K01 - K01NS073700 (2012-2017)
NIDA R21/R33 - DA041876-01 (2016-2018; R21 phase)
UNCF-Merck Postdoctoral Fellowship (2007-2009)
Neurogenomics Training Grant 5T32MH065215-04 (2006-2007)
Research in the Baucum laboratory focuses on the identification and characterization of synaptic protein complexes in a brain region called the striatum. The striatum is critical in allowing for fine motor control as well as being responsible for multiple effects of drugs of abuse. A decrease in dopamine innervation to the striatum underlies motor deficits associated with normal aging and age-related pathological conditions such as Parkinson Disease. Moreover, enhanced dopaminergic tone via blockade of dopamine reuptake or enhanced dopamine release caused by drugs of abuse such as cocaine and amphetamine can lead to motor and euphoric effects. How modulation of dopaminergic tone effects synaptic signaling and synaptic protein complexes in striatal medium spiny neurons has not been fully characterized.
The lab focuses on a synaptic protein, spinophilin, which is known to act as a scaffold, bringing multiple proteins together to allow for efficient organization and signaling. In particular, spinophilin binds to F-actin and can regulate actin and spine dynamics. Also, it binds to protein phosphatase 1 to target this phosphatase to various substrates, allowing for modulation of normal signaling. In collaboration with the proteomics core facility at IUPUI, we will be using mass spectrometry-based technologies to identify and quantify changes in specific spinophilin post-translational modifications and protein-protein interactions in animal models of Parkinson Disease and following exposure to drugs of abuse. These studies will be followed up with biochemical and imaging-based technologies to further characterize and understand the role that altered spinophilin signaling and protein complexes have on regulating changes observed under pathological conditions.