Randall Roper, Ph.D.Biology Associate Professor, Biomedical Engineering Adjunct Associate Professor, Biology Department
B.S. Microbiology (Molecular Biology emphasis), Brigham Young University, Provo, UT
Ph.D. Immunology and Genetics, University of Illinois at Urbana-Champaign, Urbana, IL
Postdoctoral Fellow, Genetics and Development, The Johns Hopkins University School of Medicine, Baltimore, MD
Courses Taught / Teaching
BME 38100: Implantable Materials and Biological Response
BIOL 56400: Molecular Genetics and Development
Our research seeks to understand the genetic and developmental bases of phenotypes related to Trisomy 21 or Down syndrome (DS). We have examined skeletal malformations associated with DS including the typical craniofacial features seen in all individuals with DS as well as changes to the appendicular skeleton.
Using mouse models of Down syndrome, our work provided the first experimental evidence that trisomy adversely affects neural crest cells, precursors to the craniofacial skeleton.
Currently we are performing preclinical studies to test treatments for specific DS traits by targeting gene products that are overexpressed because of trisomy. Additionally, we are examining changes in expression of trisomic genes as well as others throughout the genome and correlating this information with phenotypic and developmental alterations. In collaboration with the Down Syndrome Clinic at Riley Hospital, we are also defining the co-occurrence and variability of debilitating traits in infants with DS.
Through our preclinical, genetic and phenotypic studies, we will better define how three copies of genes on human chromosome 21 cause traits associated with DS as well as understand how genetic variability affects the severity of DS traits. Our long term goal is to apply the knowledge of how and when trisomic genes affect developmental processes to ameliorate Trisomy 21 phenotypes.
Publications & Professional Activities
Blazek J.D., Abeysekera I., Li J., Roper R.J. Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a. Hum Mol Genet. 2015; 24:5687-96. Epub 2015 Jul 23.
Stringer M., Abeysekera I., Dria K.J., Roper R.J., Goodlett C.R. Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model. Pharmacol Biochem Behav. 2015; 138:70-79. [Epub ahead of print]
Blazek, J.D., A. M. Malik, M. Tischbein, M. L. Arbones, C. S. Moore and R. J. Roper. 2015. Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner. Mech Dev. 136:133-42. Epub 2014 Dec 30.
Goffinski, A., M.A. Stanley, N. Shepherd, N. Duvall, S.B. Stone, C. Davis, M.J. Bull, and R.J. Roper. 2015. Obstructive Sleep Apnea in Young Infants with Down Syndrome Evaluated in a Down Syndrome Specialty Clinic. Am J Med Genet A. 167:324-30. Epub 2015 Jan 13.
Solzak, J.P., Y. Liang, F.C. Zhou and R.J. Roper. 2013. Commonality in Down and Fetal Alcohol Syndromes. Birth Defects Res A Clin Mol Teratol. 97:187-97. Epub 2013 Apr 3.
Billingsley, C.N., J.A. Allen, S.L. Deitz, J.D. Blazek, D.D. Baumann, A. Newbauer, A. Darrah, B.C. Long, B. Young, M. Clement, R.W. Doerge, and R.J. Roper. 2013. Non-trisomic homeobox gene and Sox9 expression alters craniofacial development in a Down syndrome mouse model. Am J Med Genet A. 161:1866-74. Epub 2013 Jul 10.
Deitz, S.L. and R.J. Roper. 2011. Trisomic and allelic differences influence phenotypic variability during development of Down syndrome mice. Genetics 189:1487-95. Epub 2011 Sep 16..
Blazek, J.D., A. Gaddy, R. Meyer, R.J. Roper, and J. Li. 2011. Disruption of bone homeostasis by trisomy in Ts65Dn Down syndrome mice. Bone 48:275-280. Epub 2010 Sep 24.
Blazek, J.D., C.N. Billingsley, A. Newbauer, and R.J. Roper. 2010. Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome. Dev Dyn. Jun;239(6):1645-53.
Roper, R.J., J.F. VanHorn, C. Cain, and R.H. Reeves. 2009. A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog. Mech Dev. 126:212-9. Epub 2008 Nov 21.
Roper, R.J. and R.H. Reeves. 2006. Understanding the basis for Down syndrome phenotypes. PLoS Genet. Mar;2(3):e50.
Roper, R.J., L.L. Baxter, N.G. Saran, D.K. Klinedinst, P.A. Beachy and R.H. Reeves. 2006. Defective cerebellar response to mitogenic Hedgehog signaling in Down syndrome mice. Proc Natl Acad Sci U S A. 103:1452-6. Epub 2006 Jan 23.
American Association for the Advancement of Science
American Society of Human Genetics
Trisomy 21 Research Society
International Mammalian Genome Society
Indiana University Center for Regenerative Biology and Medicine
Editorial Board, The Scientific World Journal
Editorial Board, Advances in Medicine
Institutional Health and Safety Committee, Butler University
Honors, Awards and Grants
Alvin S. Bynum Mentoring Award for Faculty at IUPUI 2015
IUPUI Athletics Favorite Professor Award 2014
Director's Mentoring Award for Outstanding Leadership and Mentoring of Undergraduate Research, Center for Research and Learning, IUPUI 2011
Inspire Award Finalist-Education, College Mentors for Kids, Indianapolis, IN 2011
IUPUI Trustees Teaching Award 2010
Louis Stokes Alliance for Minority Participation (LSAMP) Mentor of the Year 2010
IUPUI Honors Program Research Fellow 2007-2010