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Welcome to the Blazer-Yost Research Laboratory. Our current research involves understanding the role of TRPV4 in Hydrocephalus, and Fluid Homeostasis in Polycystic Kidney Disease. We utilize Ussing Chamber Electrophysiology, Immunohistochemistry, as well as various Molecular Biology techniques to understand these processes.

Hydrocephalus Project

Current research involving Modulation of TRPV4 Activity.

Polycystic Kidney Disease Project

Salt Regulation and Fluid Homeostasis in Renal Cells.

Meet the Lab

  • Dr. Bonnie Blazer-Yost, Ph.D

    Professor of Biology, IUPUI
    with joint appointments in
    Cell and Integrative Physiology, IUSM
    Anatomy and Cell Biology, IUSM

  • Lab Members

    The People who do their best
    to keep Dr. Blazer-Yost
    out of the lab

Current Publications

    Blazer-Yost, B.L. Chapter 25 ADPKD Channel - The Polycystins. In Ion Channels and Transporters of Epithelia in Health and Disease. Editors K.L. Hamilton, D.C. Devor, B.J. Harvey. Springer, 2015

    Banga, A., S. Flaig, S. Lewis, S. Winfree, B. L. Blazer-Yost. Epinephrine stimulation of anion secretion in the Calu-3 serous cell model. Am. J. Physiol. Lung Mol. Physiol. 306:L937-L946, 2014

    Li, P., X. Lai, F. Witzmann, B.L. Blazer-Yost. Bioinformatic Analysis of Differential Protein Expression in Calu-3 Cells Exposed to Carbon Nanotubes. Proteomes 1:219-239 doi: 10.3390/proteomes 1030219, 2013.

    Lai, X., B.L. Blazer-Yost, J.W. Clack, S.L. Fears, S. Mitra, S.A. Ntim, H.N. Ringham and F.A. Witzmann. Protein expression profiles of intestinal epithelial co-cultures: Effect of functionalized carbon nanotube exposure. Int. J. Biomed. Nanosci. Nanotech. 3:127-162, 2013.

    Banga, A. F.A. Witzmann, H. Petrache, and B.L. Blazer-Yost. Functional effects of nanoparticle exposure on Calu-3 airway epithelial cells. Cell. Physiol. Biochem. 29: 197-212, 2012.

    Blazer-Yost, B.L., A. J. Banga, A. Amos, E. Chernoff, X. Lai, C. Li, S. Mitra and F.A. Witzmann. Effect of carbon nanoparticles on barrier function of renal epithelial cells. Nanotoxicology 5: 354-371, 2011

    Blazer-Yost, B. L., B. J. Blacklock, S. Flaig, R. L. Bacallao and V. Gattone. Lysophosphatidic Acid is a Modulator of Cyst Growth in Autosomal Dominant Polycystic Kidney Disease. Cell. Physiol. Biochem. 278: 1255-1264, 2011

    Blazer-Yost, B.L. PPARγ Agonists - Blood Pressure and Edema. PPAR Research Volume 2010, Article ID 785369, 5 pages doi:10.1155/2010/785369, 2010.

    Blazer-Yost, B.L., J. Haydon, T. Eggleston-Gulyas, J-H. Chen, X. Wang, V. Gattone and V.E. Torres. Pioglitazone attenuates cystic burden in the PCK rodent model of polycystic kidney disease. PPAR Research. Article ID 274376, 8 pages doi:10.1155/2010/274376, 2010

    Menniti, M., R. Iuliano, M. Sopjani, M. Foller, S. Mariggio, C. Nofziger, A.M. Perri, R. Amato, B. Blazer-Yost, D. Corda, F. Lang and N. Perrotti. 60 kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC. Cell. Physiol. Biochem. 26:587-596, 2010