AJ Baucum - In the Baucum laboratory, we use biochemistry, electrophysiology, proteomics, and behavioral measures to study synaptic proteins that regulate normal signal transduction pathways in neurons. These synaptic proteins are indispensable for myriad learned behaviors, from motor coordination and learning to memory. Our laboratory uses genetically engineered animals to determine the function of the protein phosphatase 1 targeting proteins, spinophilin and neurabin, in different brain regions and cell types on regulating motor and non-motor learning.
Teri Belecky-Adams - The Belecky-Adams laboratory examines several aspects of visual system function, including 1) the dynamics of chromatin organization in retinal and optic nerve development and disease, 2) understanding the photoreceptor in health and disease, 3) the regeneration of the retina and optic nerve. Our findings can be directly translated into new preventative and therapeutic tools for the treatment of such diseases as glaucoma, retinitis pigmentosa, and Joubert syndrome.
Nicolas Berbari - The Berbari lab studies small hair-like cellular appendages called primary cilia. Cilia dysfunction is associated with a growing group of rare genetic disorders collectively called the ciliopathies. By studying models of ciliopathies we will reveal more about their basic biology and ultimately contribute to our understanding of more common clinical features observed in the ciliopathies such as obesity, retinal degeneration and cognitive deficits. The current focus of the lab is to understand how primary cilia found on neurons in the brain are important for regulating appetite and feeding behavior.
Bonnie Blazer-Yost - The Blazer-Yost research group is investigating the development of hydrocephalus or "water on the brain". While most notable in newborns, hydrocephalus can occur at any age as a result of stroke, infection, traumatic brain injury or neurodegenerative disease. We are using cell culture and animal models to study hydrocephalus with a long-term goal of developing the first pharmaceutical treatment for the disease.
Ted Cummins - The Cummins lab research focuses on cellular and molecular determinants of electrical excitability. In particular, the role of voltage-gated sodium channels in human diseases such as epilepsy and pain are being investigated.
Guoli Dai - The Dai laboratory's research focuses on understanding the regulation of the cell cycle of proliferating hepatocytes and hepatic progenitor cell activities in liver physiology and pathology. Major approaches include partial hepatectomy-induced hepatocyte replication and in vivo fate tracing of hepatic progenitor cells.
Jiliang Li - The Li laboratory research activities include understanding the molecular and cellular mechanisms of mechanotransduction, the process of conversion of mechanical signals into biological signals in bone cells, and studying cell based therapy for bone fracture repair and tissue regeneration.
James Marrs - The Marrs lab's research uses zebrafish to model fetal alcohol syndrome (FAS; the most severe clinically defined birth defect syndrome caused by prenatal ethanol exposure, which is a subset of fetal alcohol spectrum disorder, FASD, an inclusive term for all defects induced by perinatal maternal ethanol consumption). A detailed understanding of alcohol-induced birth defects will guide us toward future clinical interventions.
Jason Meyer - The Meyer lab focuses on the use of human pluripotent stem cells for studies of mechanisms underlying neurogenesis as well as neurodegeneration in diseases including Glaucoma and Alzheimer's Disease.
Benjamin Perrin - The Perrin laboratory studies the organization, turnover and regulation of the actin cytoskeleton in sensory cells of the inner ear.