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Bonnie Blazer-Yost, Ph.D.

Education

B.A.    Lebanon Valley College, Annville, PA.

Ph.D.   University of Pennsylvania, Philadelphia, PA.

Post-doctoral Fellowship, Department of Pharmacology, Cambridge University, Cambridge, U.K.

Research

The kidney plays a major role in maintaining salt and fluid homeostasis.  The research interests of my laboratory are in the field of hormonal modulation of ion transport with a focus on renal epithelial Na+ transport. In the mammalian kidney, Na+ transport is precisely regulated by a variety of hormones.  The present research is examining the effects of aldosterone (a classic natriferic corticosteroid hormone), insulin (a natriferic peptide) and insulin like growth factor 1 (IGF1) (a peptide growth factor).  

We are interested in points of convergence between the steroid and peptide responses, particularly whether both classes of hormones modulate renal epithelial Na+ transport at the level of the amiloride-sensitive Na+ channel. These studies utilize the disciplines of cellular physiology, electrophysiology, protein biochemistry proteomics, confocal imaging and molecular biology.

Our studies have direct medical relevance to diseases such as essential hypertension, diabetic hypertension, polycystic kidney disease, congestive heart failure and cystic fibrosis.

Publications & Professional Activities

  1. Shim, J.W., P.R. Territo, E. Maue, S. Ahmed, J.C. Watson, L. Jiang, A.A. Riley, B. McCarthy, S. Persohn, D. Fulkerson, B.L. Blazer-Yost. Neuroanatomical consequences implicated in the Wpk rat model of Meckel Gruber Syndrome. In press Sci. Report
  2. Preston, D., S. Simpson, D. Halm, A. Hochstetler, C. Schwerk, H. Schroten, B.L. Blazer-Yost, Activation of TRPV4 in a porcine choroid plexus cell line. Am. J. Physiol. Cell Physiol. In press
  3. Kulkarni, N. R. Smith, B. L. Blazer-Yost. Loss of inversin decreases transepithelial sodium transport in murine renal cells. Am. J. Physiol. Cell Physiol. 313:C664-C673, 2017
  4. Irsik, D.L., B.L. Blazer-Yost, A. Staruschenko, M.M. Brands. The normal increase in insulin after a meal is required to prevent postprandial renal sodium and volume losses. Am. J. Physiol: Reg. Integr. Comp. Physiol. 312: R965-R972, 2017
  5. Flaig, S. V. Gattone, B.L. Blazer-Yost. Inhibition of cyst growth in PCK and Wpk rat models of polycystic kidney disease with low doses of PPAR? agonists. J. Translational Internal Med. 4: 118-126, 2016. DOI: 10.1515/jtim-2016-0028 [PubMed]
  6. Shim J.W., J. Sandlund, M.Q. Hameed, B.L. Blazer-Yost, J.R. Madsen. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus. Sci. Rep. Sci 6:26794. doi: 10.1038/srep26794, 2016

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