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Guoli Dai, Associate Professor


Post-Doctoral: University of Kansas Medical Center, Kansas City, KS

Post-Doctoral: Albert Einstein Medical Center, Philadelphia, PA.

PhD: College of Agricultural and Animal Sciences, Jilin University, P.R. China.

MS: Changchun Veterinary University, Changchun, P.R. China.

DVM: Changchun Veterinary University, Changchun, P.R. China.

Courses Taught / Teaching

Biology 55900: Endocrinology


My research interests focus on two major aspects. The first is to understand the mechanisms governing liver regeneration. At the cellular level, I investigate the regulation of the cell cycle of replicating hepatocytes and the activities of liver progenitor cells in injured liver. At the molecular level, I study how the prolactin receptor transduces mitogenic signaling driving hepatocyte proliferation to compensate for the loss of liver mass. I am also interested in deciphering how TGF-B signaling mediates liver injury-induced skeletal muscle wasting.  The second is to understand how maternal liver adapts to pregnancy.  Ongoing projects are to elucidate the functions of the prolactin receptor and transcription factor Ascl1 in regulating maternal liver growth and mediating the cross-talk between maternal liver and other maternal organs during pregnancy. The ultimate goal is to develop approaches to treat liver disorders and their complications. 

Publications & Professional Activities

Jackson Nteeba, Kaiyu Kubota, Wenfang Wang, Hao Zhu, Jay L. Vivian, Guoli Dai, and Michael J. Soares. 2019. Pancreatic Prolactin Receptor Signaling Regulates Maternal Glucose Homeostasis. Journal of Endocrinology. pii: JOE-18-0518.R2. doi: 10.1530/JOE-18-0518

Khambu B, Huda N, Chen X, Antoine DJ, Li Y, Dai G, Kohler UA, Zong WX, Waguri S, Werner S, Oury TD, Dong Z, Yin XM. 2018. HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. J Clin Invest. Jun 1;128(6):2419-2435.

Le Y, Chen L, Zhang Y, Bu P, Dai G, Cheng X. 2017. Epalrestat Stimulated Oxidative Stress, Inflammation and Fibrogenesis in Mouse Liver. Toxicol Sci. 2017 Feb 15.

Rui W, Zou Y, Lee J, Nambiar SM, Lin J, Zhang L, Yang Y, Dai G. 2016. Nuclear Factor Erythroid 2-Related Factor 2 Deficiency Results in Amplification of the Liver Fat-Lowering Effect of Estrogen. J Pharmacol Exp Ther. 2016 Jul;358(1):14-21

Zou Y, Hu M, Lee J, Nambiar SM, Garcia V, Bao Q, Chan JY, Dai G. 2015. Nrf2 is Essential for timely M phase entry of replicating hepatocytes during liver regeneration. Am J Physiol Gastrointest Liver Physiol. Feb 15;308(4):G262-8.

Sun YX, Li L, Corry KA, Zhang P, Yang Y, Himes E, Mihuti CL, Nelson C, Dai G, Li J. 2015. Deletion of Nrf2 reduces skeletal mechanical properties and decreases load-driven bone formation. Bone. May;74:1-9.

Yuhong Zou, Joonyong Lee, Shashank Manohar Nambiar, Min Hu, Wenjuan Rui, Qi Bao, Jefferson Y. Chan and Guoli Dai. 2014. Nrf2 Is Involved in Maintaining Hepatocyte Identity during Liver Regeneration. PLoS ONE, 15;9(9):e107423

Min Hu, Yuhong Zou, Shashank Manohar Nambiar, Joonyong Lee, Yan Yang and Guoli Dai. 2014. Keap1 Modulates the Redox Cycle and Hepatocyte Cell Cycle in Regenerating Liver. Cell Cycle, May 27;13(15).

Benjamin C. Yaden, Johnny E. Croy, Yan Wang, John M. Wilson,  Amita Datta-Mannan, Pamela Shetler, Andrea Milner, Jessica Andrews, Henry U. Bryant, Guoli Dai and Venkatesh Krishnan. 2014. Follistatin: A Novel Therapeutic for the Improvement of Muscle Regeneration. Journal of Pharmacology and Experimental Therapeutics, May;349(2):355-71.

BC Yaden, Y Wang, J Croy, A Milner, J Wilson, P Shelter, G Dai, and VK Krishnan.2013. Inhibition of Activin A Ameliorates Skeletal Muscle Injury and Rescues Contractile Properties in Mice. American Journal of Pathology, Apr;184(4):1152-66.

Kwok SC, Kumar S, and Dai G. 2014. Characterization of a Variant of ERGIC2 Transcript. DNA and Cell Biology, Feb;33(2):73-8.

Kwok SC, Chakraborty D, Soares MJ, and Dai G. 2013. Relative Expression of Proprotein Convertases in Rat Ovaries during Pregnancy. Journal of Ovarian Research, Dec 11;6(1):91.

Yuhong Zou, Min Hu, Qi Bao, Jefferson Y. Chan and Guoli Dai. 2013. Nrf2 Participates in Regulating Maternal Hepatic Adaptations to Pregnancy. Journal of Cell Science, Apr 1;126(Pt 7):1618-25.

Sudhanshu Kumar, Yuhong Zou, Qi Bao, Mu Wang, and Guoli Dai. 2012. A Proteomic Analysis of Immediate-Early Response Plasma Proteins after 70% and 90% Partial Hepatectomy. Hepatology Research, Nov 27. doi: 10.1111/hepr.12030. (The first and second authors equally contribute).

Y Zou, Q Bao, S Kumar, M Hu, GY Wang, G Dai. 2012. Four Waves of Hepatocyte Proliferation Linked with Three Waves of Hepatic Fat Accumulation during Partial Hepatectomy-Induced Liver Regeneration. PLoS ONE, 7(2):e30675.

G Dai, J Bustamante, Y Zou, A Myronovych, Q Bao, S Kumar, and MJ Soares. 2011. Maternal Hepatic Growth Response to Pregnancy in the Mouse.  Experimental Biology and Medicine, 236:1322-1332.

J Bustamante, BL Copple, MJ Soares, G Dai.  2010. Gene Profiling of Maternal Hepatic Adaptations to Pregnancy. Liver International, 30(3):406-415.

G Dai, L He, P Bu, and YJ Wan. 2008. Pregnane X Receptor Is Required for Normal Progression of Liver Regeneration. Hepatology, 47(4):1276-1287

J Bustamante, G Dai, and MJ Soares. 2008. Pregnancy and Lactation Modulate Maternal Splenic Growth and Development of the Erythroid Lineage in the Rat and Mouse. Reproduction, Fertility and Development, 20(2):303-310

SM Alam, T Konno, G Dai, L LU, D Wang, JH Dunmore, AR Godwin, MJ Soares. 2007. A Uterine Decidual Cell Cytokine Ensures Pregnancy-dependent Adaptations to A Physiological Stressor. Development, 134(2):407-15.

G Dai, N Chou, L He, and YJ Wan. 2006. Acetaminophen Metabolism Does Not Contribute to Gender Difference in Its Hepatotoxicity in Mouse. Toxicological Sciences, 92(1):33-41.

MA Gyamfi, MG Kocsis, L He, G Dai, AJ Mendy, YJ Wan. 2006. The Role of Retinoid X Receptor in Regulating Alcohol Metabolism. Journal of Pharmacology and Experimental Therapeutics, 319(1):360-368.

K Wang, AJ Mendy, G Dai, HR Luo, L He, and YJ Wan. 2006. Retinoids Activate the RXR/SXR-mediated Pathway and Induce the Endogenous CYP3A4 Activity in Huh7 Human Hepatoma Cells. Toxicological Sciences, 92(1):51-60.

G Dai, N Chou, L He, MA Gyamfi, JA Mendy, AL Slitt, CD Klaassen, and YJ Wan. 2005.  Retinoid X Receptor Alpha Regulates the Expression of Glutathione S-transferase Genes and Modulates Acetaminophen-glutathione Conjugation in Mouse Liver. Molecular Pharmacology, 68(6):1590-1596.

V Rider, T Potapova, G Dai, and MJ Soares. 2005. Stimulation of A Rat Uterine Stromal Cell Line in Culture Reveals A Molecular Switch for Endocrine-dependent Differentiation. Journal of Endocrinology, 184(1):119-27.

G Dai and YJ Wan. 2005. Animal Models of Xenobiotic Receptors. Current Drug Metabolism, 6(4):341-355.

R Ain, G Dai, J Dunmore, A Godwin, and M Soares. 2004. A Prolactin Family Paralog Regulates Reproductive Adaptations to A Physiological Stressor. Proc. Natl. Acad. Sci. U S A., 23;101(47):16543-8.

S Lee, G Dai, Z Hu, X Wang, J Du, and W Mitch. 2004. Regulation of Muscle Protein Degradation: Coordinated Control of Apoptotic and Ubiquitin-proteasome Systems by Phosphatidylinositol 3 Kinase. Journal of the American Society of Nephrology, 15(6):1537-45. (The first and second authors equally contribute).

D Wiemers, L Shao, R Ain, G Dai, and M Soares. 2003. The Mouse Prolactin Gene Family Locus. Endocrinology, 44(1):313-25.

G Dai, L Lu, S Tang, N Sahgal, and M Soares. 2002. Prolactin Family Miniarray: A Tool for Evaluating Uteroplacental-trophoblast Endocrine Cell Phenotypes. Reproduction, 24(6):755-65.

T Kamei, S Jones, B Chapman, K MCGonigle, G Dai, and M Soares. 2000. The Phosphatidylinositol 3-kinase/Akt Signaling Pathway Modulates the Endocrine Differentiation of Trophoblast Cells. Molecular Endocrinology, 6(7):1469-81.

D Wang, R Ishimura, DS Walia, H Muller, G Dai, JS Hunt, N A Lee, JJ Lee, and MJ Soares. 2000. Eosinophils Are Targets For A Novel Uteroplacental Heparin-Binding Cytokine Decidual / Trophoblast Prolactin-related Protein. Journal of Endocrinology, 166:1-15.

G Dai, D Wang, B Liu, J W Kasik, H Muller, RA White, GS Hummel, and MJ Soares. 2000. Three Novel Paralogs of the Rodent Prolactin Gene Family. Journal of Endocrinology, 166:63-75.

N Sahgal, GT Knipp, B Liu, BM Chapman, G Dai, and MJ Soares. 2000. Identification of Two New Nonclassical Members of the Rat Prolactin Family. Journal of Molecular Endocrinology, 24: 95-105.

RH Renegar, CR Owens, G Dai, JP McMurtry, and SCM Kwok. 2000. Expression and Localization of Prohormone Convertase 1/3 (SPC3) in Porcine Ovary. Molecular Reproduction and Development. 57(4):361-5.

G Dai, MW Wolf, and MJ Soares. 1999. Distinct Regulatory Regions from the Prolactin-like Protein-C Variant Promoter Direct Trophoblast Giant Cell versus Spongiotrophoblast Cell-specific Expression. Endocrinology, 140: 4691-4698.

H Muller, B Liu, BA Croy, JR Head, JS Hunt, G Dai, and MJ Soares. 1999. Uterine Natural Killer Cells Are Targets For A Trophoblast Cell-Specific Cytokine, Prolactin-Like Protein-A. Endocrinology, 140: 4032-4039.

G Dai, BM Chapman, D Wang, RA White, and MJ Soares. 1999. Prolactin-like Protein-A Gene Structure and Chromosomal Mapping. Mammalian Genome, 10: 78-80.

H Mueller, G Dai, and MJ Soares. 1998. Placental Lactogen-I (PL-I) Target Tissues Identified With an Alkaline Phosphatase-PL-I Fusion Protein. The Journal of Histochemistry & Cytochemistry, 46(6): 737-743.

KE Orwig, MW Wolfe, CB Cohick, G Dai, TJ Peters and MJ Soares. 1998. Trophoblast-specific Regulation of Endocrine-related Genes. Trophoblast Research, 11:65-85.

G Dai, B Liu, BM Chapman and MJ Soares. 1998. A New Member of the Mouse Prolactin (PRL)-like Protein-C Subfamily, PRL-like Protein-Ca : Structure and Expression. Endocrinology, 139(12): 5157-5163.

MJ Soares, H Muller, KE Orwig, TJ Peter, and G Dai. 1997. The Uteroplacental Prolactin Family and Pregnancy. Biology of Reproduction, 58:273-284.

KE Orwig, G Dai, CA Rasmussen and MJ Soares. 1997. Decidual/Trophoblast  Prolactin-related Protein: Characterization of Gene Structure and Cell-specific Expression. Endocrinology,138:2491-2500.

G Dai, W Imagawa, B Liu, C Szpirer, G Levan, SCM Kwok and MJ Soares.1996. Rcho-1 Trophoblast Cell Placental Lactogens: Complementary DNA, Heterologous Expression, and Biological Activities. Endocrinology, 137:5020-5027.

MJ Soares, G Dai, CB Cohick, H Mueller, and KE Orwig. 1996. The Rodent Placental Prolactin and Pregnancy. In: Endocrinology of Pregnancy, F.W. Bazer(ed), Humana Press Inc., New Jersey.

G Dai, B Liu, C Szpirer, G Levan, SCM Kwok and MJ Soares. 1996. Prolactin-like Prolactin C Variant: Complementary DNA, Unique Six Exon Gene Structure, and Trophoblast Cell-Specific Expression. Endocrinology, 137:5009-5019.

MJ Soares, BM Chapman, CB Cohick, CA Rasmussen, G Dai, T Kamei and KE Orwig. 1996. Differentiation of Trophoblast Endocrine Cells. Placenta, 17:277-289.

CB Cohick, G Dai, L Xu, S Deb, T Kamei, G Levan, C Szpirer, SCM Kwok and MJ Soares. 1996. Placental Lactogen-I Variant Utilizes the Prolactin Receptor Signaling Pathway. Molecular and Cellular Endocrinology, 116:49-58.

G Dai, SP Smeekens, DF Steiner, JP McMurtry and SCM Kwok.1995. Characterization of Multiple Prohormone Convertase PC1/3 Transcripts in Porcine Ovary. Biochimica et Biophysica Acta, 1264:1-6.

SCM Kwok, G Dai and JP McMurtry. 1994. Molecular Cloning and Sequence Analysis of the cDNA Encoding Porcine Acrosin Inhibitor. DNA and Cell Biology, 13:389-394.

SCM Kwok, D Yang, G Dai, MJ Soares, S Chen and JP McMurtry. 1993. Molecular Cloning and Sequence Analysis of Two Porcine Seminal Proteins, PSP-I and PSP-II: New Members of the Spermadhesin Family. DNA and Cell Biology, 12:605-610.

Professional Affiliations

American Association for the Advancement of Science (AAAS)

American Association for the Study of Liver Diseases (AASLD)